Covid Vaccine Boosters Not “Appropriate” At This Stage: Lancet Study | News

September 13, 2021 0 Comments



Even if some gain can ultimately be obtained from boosting, it will not outweigh the benefits of providing initial protection to the unvaccinated against COVID-19: Experts

Highlights
  • Vaccinating people can help hasten the end of the pandemic: Experts
  • The vaccines that are currently available are safe, effective: WHO
  • Vaccination had 95% efficacy against severe disease: Experts

New Delhi: Vaccine efficacy against severe COVID-19, even for the delta variant, is so high that booster doses for the general population are not appropriate at this stage in the pandemic, according to a review by an international group of scientists published in The Lancet on Monday (September 13). The review by experts, including those from the World Health Organisation (WHO) and the US Food and Drug Administration (FDA)summarised the currently available evidence from randomised controlled trials and observational studies published in peer-reviewed journals and pre-print servers.

Also Read: COVID-19 Vaccines Highly Effective In Preventing Hospitalisation And Emergency Visits: US Study

The results reported from the observational studies, on average, show that vaccination had 95 per cent efficacy against severe disease both from the Delta variant and from the Alpha variant, and over 80 per cent efficacy at protecting against any infection from these variants.

The authors noted that across all vaccine types and variants, vaccine efficacy is greater against severe disease than against mild disease. Although vaccines are less effective against asymptomatic disease or against transmission than against severe disease, even in populations with high vaccination coverage the unvaccinated minority are still the major drivers of transmission, as well as being themselves at the highest risk of serious disease, they said.

Taken as a whole, the currently available studies do not provide credible evidence of substantially declining protection against severe disease, which is the primary goal of vaccination. The limited supply of these vaccines will save the most lives if made available to people who are at appreciable risk of serious disease and have not yet received any vaccine, said lead author Ana-Maria Henao-Restrepo from WHO.

The authors noted that even if some gain can ultimately be obtained from boosting, it will not outweigh the benefits of providing initial protection to the unvaccinated. If vaccines are deployed where they would do the most good, they could hasten the end of the pandemic by inhibiting further evolution of variants, they added.

Also Read: COVID-19: G20 Health Ministers Agree Vaccine Confidence Measures

The authors explained that even if levels of antibodies in vaccinated individuals wane over time, this does not necessarily predict reductions in the efficacy of vaccines against severe disease. This could be because protection against severe disease is mediated not only by antibody responses, which might be relatively short lived for some vaccines, but also by memory responses and cell-mediated immunity, which are generally longer-lived, they said.

The vaccines that are currently available are safe, effective, and save lives. Although the idea of further reducing the number of COVID-19 cases by enhancing immunity in vaccinated people is appealing, any decision to do so should be evidence-based and consider the benefits and risks for individuals and society, said study co-author Soumya Swaminathan, WHO Chief Scientist.

According to the review, if boosters are ultimately to be used, there will be a need to identify specific circumstances where the benefits outweigh the risks. The authors also noted that the ability of vaccines to elicit an antibody response against current variants indicates that these variants have not yet evolved to the point at which they are likely to escape the memory immune response induced by the vaccines.

Even if new variants that can escape the current vaccines are going to evolve, they are most likely to do so from strains that have already become widely prevalent, they said. Therefore, the authors said, the effectiveness of boosters developed specifically to match potential newer variants could be greater and longer lived than boosters using current vaccines. A similar strategy is used for influenza vaccines, for which each annual vaccine is based on the most current data about circulating strains, increasing the likelihood that the vaccine will remain effective even if there is further strain evolution, they added.

Also Read: Full Vaccination Prerequisite If Attending Mass Gathering Essential: Govt Ahead Of Festive Season

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV – Dettol Banega Swasth India campaign is an extension of the five-year-old Banega Swachh India initiative helmed by Campaign Ambassador Amitabh Bachchan. It aims to spread awareness about critical health issues facing the country. In wake of the current COVID-19 pandemic, the need for WASH (WaterSanitation and Hygiene) is reaffirmed as handwashing is one of the ways to prevent Coronavirus infection and other diseases. The campaign highlights the importance of nutrition and healthcare for women and children to prevent maternal and child mortality, fight malnutrition, stunting, wasting, anaemia and disease prevention through vaccines. Importance of programmes like Public Distribution System (PDS), Mid-day Meal Scheme, POSHAN Abhiyan and the role of Aganwadis and ASHA workers are also covered. Only a Swachh or clean India where toilets are used and open defecation free (ODF) status achieved as part of the Swachh Bharat Abhiyan launched by Prime Minister Narendra Modi in 2014, can eradicate diseases like diahorrea and become a Swasth or healthy India. The campaign will continue to cover issues like air pollutionwaste managementplastic banmanual scavenging and sanitation workers and menstrual hygiene

World

22,52,53,121Cases

18,81,30,045Active

3,24,84,159Recovered

46,38,917Deaths

Coronavirus has spread to 195 countries. The total confirmed cases worldwide are 22,52,53,121 and 46,38,917 have died; 18,81,30,045 are active cases and 3,24,84,159 have recovered as on September 14, 2021 at 3:37 am.

India

3,32,89,579 25,404Cases

3,62,20712,062Active

3,24,84,159 37,127Recovered

4,43,213 339Deaths

In India, there are 3,32,89,579 confirmed cases including 4,43,213 deaths. The number of active cases is 3,62,207 and 3,24,84,159 have recovered as on September 14, 2021 at 2:30 am.

State Details

State Cases Active Recovered Deaths
Maharashtra

65,00,617 2,740

53,427 2,183

63,09,021 530

1,38,169 27

Kerala

43,90,489 15,058

2,09,335 13,480

41,58,504 28,439

22,650 99

Karnataka

29,62,408 673

16,269 414

29,08,622 1,074

37,517 13

Tamil Nadu

26,35,419 1,580

16,522 49

25,83,707 1,509

35,190 22

Andhra Pradesh

20,30,849 864

14,652 458

20,02,187 1,310

14,010 12

Uttar Pradesh

17,09,555 8

175 2

16,86,497 10

22,883

West Bengal

15,57,414 506

8,096 91

15,30,731 587

18,587 10

Delhi

14,38,250 17

377 13

14,12,790 30

25,083

Odisha

10,16,833 471

5,919 217

10,02,810 682

8,104 6

Chhattisgarh

10,04,902 38

376 0

9,90,968 38

13,558

Rajasthan

9,54,198 8

90 1

9,45,154 7

8,954

Gujarat

8,25,629 12

161 4

8,15,386 16

10,082

Madhya Pradesh

7,92,353 12

131 7

7,81,705 19

10,517

Haryana

7,70,659 14

351 141

7,60,501 34

9,807 121

Bihar

7,25,833 6

77 4

7,16,098 10

9,658

Telangana

6,61,866 315

5,253 5

6,52,716 318

3,897 2

Punjab

6,01,072 32

309 3

5,84,306 25

16,457 4

Assam

5,95,669 564

5,615 87

5,84,296 644

5,758 7

Jharkhand

3,48,079 6

117 10

3,42,829 16

5,133

Uttarakhand

3,43,242 19

293 19

3,35,560 38

7,389

Jammu And Kashmir

3,26,990 86

1,247 38

3,21,329 124

4,414

Himachal Pradesh

2,15,893 202

1,521 15

2,10,733 214

3,639 3

Goa

1,74,891 54

702 36

1,70,972 90

3,217

Puducherry

1,24,836 61

860 70

1,22,153 131

1,823

Manipur

1,17,230 136

2,617 130

1,12,801 265

1,812 1

Tripura

83,672 52

485 20

82,382 72

805

Meghalaya

78,359 226

1,859 46

75,141 177

1,359 3

Mizoram

72,883 1,502

13,369 973

59,273 526

241 3

Chandigarh

65,160 6

32 2

64,311 4

817

Arunachal Pradesh

53,807 75

533 7

53,004 68

270

Nagaland

30,657 27

580 38

29,432 59

645 6

Sikkim

30,650 26

809 27

29,464 53

377

Ladakh

20,608 4

30 0

20,371 4

207

Dadra And Nagar Haveli

10,670

5 1

10,661 1

4

Lakshadweep

10,353 2

5 2

10,297

51

Andaman And Nicobar Islands

7,584 2

8 1

7,447 3

129





Source

Leave a Reply

Your email address will not be published. Required fields are marked *