Organ Transplant Recipients Vulnerable To COVID-19 Even After Vaccination: Study | News
Highlights
- Transplant recipients must continue to practice COVID safety norms: Study
- Transplant recipients may not develop stronger immune response: Study
- The study analysed 658 participants who received organ transplant
New Delhi: Although two doses of a COVID-19 vaccine confer some protection for people who have received solid organ transplants, it’s still not enough to enable them to dispense with masks, physical distancing and other safety measures, according to a study. This is a follow-up study to an earlier one in which the researchers reported that only 17 per cent of the participating transplant recipients produced sufficient antibodies after just one dose of a two-dose COVID-19 vaccine regimen.
Also Read: COVID-19 Vaccine Delivery By Age May Mitigate Deaths And Severe Health Impacts: Study
Study lead author Brian Boyarsky from the Johns Hopkins University School of Medicine in the US said,
While there was an increase in those with detectable antibodies after the second shot, the number of transplant recipients in our second study whose antibody levels reached high enough levels to ward off infection was still well below than in people with healthy immune systems. Based on our findings, we recommend that transplant recipients and other immunocompromised patients continue to practice strict COVID-19 safety precautions, even after vaccination.
The researchers noted that people who receive solid organ transplants, such as hearts, lungs and kidneys, often must take drugs to suppress their immune systems and prevent rejection. Such regimens may interfere with a transplant recipient’s ability to make antibodies to foreign substances, including the protective ones produced in response to vaccines, they said.
The latest study, published in the Journal of the American Medical Association (JAMA), evaluated this immunogenic response following the second dose of either of the two mRNA vaccines — made by Moderna and Pfizer-BioNTech — for 658 transplant recipients, none of whom had a prior diagnosis of COVID-19.
The participants completed their two-dose regimen between December 16, 2020, and March 13, 2021. The researchers found that only 98 of the 658 study participants — 15 per cent — had detectable antibodies to SARS-CoV-2 at 21 days after the first vaccine dose.
This was comparable to the 17 per cent reported in the March study looking at immune response after only one vaccine dose. At 29 days following the second dose, the number of participants with detectable antibodies rose to 357 out of 658 — 54 per cent, the researchers said.
After both vaccine doses were administered, 301 out of 658 participants — 46 per cent — had no detectable antibody at all while 259 — 39 per cent — only produced antibodies after the second shot, they said. The researchers also found that among the participants, the most likely to develop an antibody response were younger, did not take immunosuppressive regimens including anti-metabolite drugs and received the Moderna vaccine. These were similar to the associations seen in the March single-dose study, they said.
Given these observations, transplant recipients should not assume that two vaccine doses guarantee sufficient immunity against SARS-CoV-2 any more than it did after just one dose, said study co-author Dorry Segev, from the Johns Hopkins University School of Medicine.
Also Read: One In Four People Experience Mild Side Effects From Covishield COVID-19 Vaccine: Lancet Study
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)
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World
15,83,20,243Cases
6,06,81,637Active
9,43,46,040Recovered
32,92,566Deaths
Coronavirus has spread to 192 countries. The total confirmed cases worldwide are 15,83,20,243 and 32,92,566 have died; 6,06,81,637 are active cases and 9,43,46,040 have recovered as on May 10, 2021 at 4:16 am.
India
2,26,62,575 366161Cases
37,45,237 8589Active
1,86,71,222 353818Recovered
2,46,116 3754Deaths
In India, there are 2,26,62,575 confirmed cases including 2,46,116 deaths. The number of active cases is 37,45,237 and 1,86,71,222 have recovered as on May 10, 2021 at 2:30 am.
State & District Details
| State | Cases | Active | Recovered | Deaths |
|---|---|---|---|---|
|
DistrictCases Mumbai45,478 Thane13,660 Pune9,920 Mumbai Suburban5,363 Aurangabad1,974 Nashik1,575 Raigad1,462 Palghar1,421 Solapur1,291 Jalgaon1,039 Akola757 Nagpur692 Kolhapur646 Satara629 Ratnagiri350 Amravati291 Dhule228 Hingoli208 Jalna201 Ahmednagar190 Nanded176 Yavatmal150 Sangli145 Latur139 Osmanabad125 Sindhudurg114 Buldhana88 Parbhani78 gondia69 Beed54 Nandurbar42 Gadchiroli42 Bhandara41 Chandrapur32 Washim13 Wardha11 |
51,01,737 48,401 |
6,18,070 12,397 |
44,07,818 60,226 |
75,849 572 |
|
DistrictCases Udupi1,176 Kalaburagi669 Yadgir538 Bengaluru Urban529 Raichur369 Mandya346 Belagavi337 Bidar219 Hassan205 Davangere204 Vijayapura201 Dakshina Kannada179 Chikkaballapura149 Mysuru107 Bagalkote103 Uttara Kannada95 Shivamogga67 Dharwad61 Ballari60 Gadag45 Bengaluru Rural40 Tumakuru36 Kolar29 Haveri24 Chikkamagaluru19 Chitradurga14 Koppal5 Kodagu4 Ramanagara3 Chamarajanagara0 |
19,34,378 47,930 |
5,64,505 15,644 |
13,51,097 31,796 |
18,776 490 |
|
DistrictCases Kannur357 Kasaragod333 Palakkad224 Malappuram119 Kollam118 Thrissur106 Thiruvananthapuram104 Pathanamthitta98 Kozhikode90 Alappuzha76 Kottayam73 Ernakulam60 Idukki40 Wayanad36 |
19,02,628 35,801 |
4,23,863 6,415 |
14,72,951 29,318 |
5,814 68 |
|
DistrictCases Gautam Buddha Nagar1,119 Agra933 Ghaziabad794 Meerut504 Lucknow386 Saharanpur298 Kanpur Nagar286 Moradabad252 Varanasi243 Hapur225 Aligarh215 Basti214 Amethi206 Rampur203 Jaunpur194 Firozabad190 Barabanki168 Gorakhpur166 Bulandshahr166 Siddharth Nagar159 Ghazipur159 Bijnor157 Deoria143 Azamgarh138 Sant Kabeer Nagar132 Mathura129 Ayodhya120 Muzaffarnagar117 Sambhal116 Sultanpur97 Ambedkar Nagar92 Maharajganj85 Amroha80 Rae Bareli78 Bahraich73 Kheri72 Kannauj69 Baghpat68 Kushi Nagar67 Bhadohi60 Ballia60 Gonda59 Etah52 Hardoi49 Balrampur49 Mau48 Mainpuri46 Etawah46 Hathras43 Unnao42 Jalaun41 Jhansi41 Shamli40 Chandauli38 Auraiya37 Farrukhabad36 Sitapur32 Prayagraj30 Banda27 Shahjahanpur25 Shravasti23 Budaun23 Mirzapur22 Bareilly17 Kasganj16 Pratapgarh15 Pilibhit15 Sonbhadra10 Kaushambi6 Kanpur Dehat4 Chitrakoot4 Lalitpur3 Hamirpur3 Mahoba3 Fatehpur3 |
15,03,490 23,175 |
2,33,981 11,755 |
12,54,045 34,636 |
15,464 294 |
|
DistrictCases Chennai23,324 Chengalpattu1,314 Thiruvallur774 Villupuram509 Kanchipuram503 Tiruvannamalai496 Cuddalore477 Ariyalur444 Tirunelveli433 Tuticorin333 Kallakurichi324 Madurai322 Salem258 Coimbatore188 Virudhunagar185 Dindigul175 Perambalur133 Ranipet133 Thanjavur130 Theni129 Tiruchirappalli119 Ramanathapuram119 Tiruppur116 Kanniyakumari110 Tenkasi103 Nagapattinam99 Karur88 Namakkal83 Erode75 Vellore71 Thiruvarur67 Pudukkottai53 Sivaganga46 Tirupathur45 Krishnagiri43 The Nilgiris17 Dharmapuri15 |
13,80,259 28,897 |
1,44,547 5,146 |
12,20,064 23,515 |
15,648 236 |
|
DistrictCases North West5,463 Central4,817 West4,768 New Delhi3,405 North3,059 East2,472 South East2,446 South West2,391 South2,329 North East1,914 Shahdara1,580 |
13,23,567 13,336 |
86,232 1,675 |
12,17,991 14,738 |
19,344 273 |
|
DistrictCases Kurnool795 Krishna557 Guntur511 Anantapur428 East Godavari356 Chittoor319 Sri Potti Sriramulu Nell*296 Y.S.R.205 West Godavari199 Srikakulam183 Prakasam104 Visakhapatnam103 Vizianagaram23 |
12,87,603 22,164 |
1,90,632 3,240 |
10,88,264 18,832 |
8,707 92 |
|
DistrictCases Kolkata2,777 Howrah1,435 24 Paraganas North1,031 Hooghly604 24 Paraganas South281 Maldah235 Dinajpur Uttar216 Coochbehar210 Birbhum206 Medinipur West159 Medinipur East153 Nadia139 Purba Bardhaman130 Murshidabad125 Bankura116 Darjeeling97 Jalpaiguri88 Paschim Bardhaman70 Purulia66 Dinajpur Dakshin50 Alipurduar39 Kalimpong18 Jhargram9 |
9,93,159 19,441 |
1,26,027 863 |
8,54,805 18,454 |
12,327 124 |
|
DistrictCases Bilaspur100 Korba100 Mungeli87 Baloda Bazar85 Jashpur77 Janjgir-Champa56 Mahasamund54 Rajnandgaon52 Kabirdham52 Raigarh47 Raipur46 Balod41 Korea39 Durg31 Bemetara21 Kanker19 Balrampur17 Surguja14 Gariyaband10 Surajpur9 Dhamtari6 Bijapur2 Bastar2 Dantewada0 Kondagaon0 Narayanpur0 Sukma0 |
8,51,476 9,120 |
1,26,547 4,312 |
7,14,359 13,243 |
10,570 189 |
|
DistrictCases Jaipur2,177 Jodhpur1,748 Udaipur724 Bharatpur563 Kota503 Nagaur500 Ajmer379 Dungarpur374 Pali352 Jhalawar329 Bhilwara250 Sikar231 Chittorgarh188 Tonk171 Jalore164 Rajsamand140 Sirohi130 Bikaner112 Banswara91 Alwar90 Churu81 Jhunjhunu64 Dausa61 Dholpur60 Baran59 Jaisalmer53 Barmer34 Hanumangarh31 SawaiMadhopur26 Karauli17 Pratapgarh14 Ganganagar8 Bundi5 |
7,56,707 17,921 |
2,00,189 882 |
5,50,853 16,880 |
5,665 159 |
|
DistrictCases Ahmadabad17,125 Surat2,311 Vadodara1,555 Gandhinagar410 Mahesana159 Banas Kantha147 Bhavnagar146 Rajkot135 Arvalli134 Mahisagar125 Anand107 PanchMahals107 Patan105 SabarKantha101 Kachchh99 Kheda98 Jamnagar63 Bharuch56 Botad55 Surendranagar55 Valsad47 GirSomnath45 Dohad43 Chhotaudepur37 Naysari35 Junagadh31 Narmada25 DevbhumiDwarka22 Amreli16 Porbandar11 Tapi6 Dang5 Morbi4 |
6,81,012 11,084 |
1,39,614 3,807 |
5,33,004 14,770 |
8,394 121 |
|
DistrictCases Indore3,839 Bhopal1,880 Ujjain799 Burhanpur351 Neemuch319 Jabalpur276 East Nimar266 Sagar228 Gwalior211 Khargone196 Dewas140 Dhar132 Mandsaur112 Morena109 Bhind87 Raisen71 Barwani60 Ratlam51 Rewa39 Shajapur39 Hoshangabad37 Vidisha37 Chhatarpur35 Betul35 Rajgarh31 Dindori29 Sheopur26 Damoh26 Satna24 Anuppur22 Panna20 Tikamgarh18 Sidhi17 Narsinghpur17 Chhindwara16 Agar Malwa15 Mandla15 Shivpuri15 Jhabua14 Shandol14 Singrauli13 Ashoknagar13 Datia12 Sehore12 Umaria10 Balaghat9 Guna8 Harda4 Alirajpur3 Katni3 Seoni2 Niwari0 |
6,71,763 11,051 |
1,08,913 6,427 |
5,56,430 4,538 |
6,420 86 |
|
DistrictCases Gurugram2,950 Faridabad867 Sonipat404 Rohtak145 Palwal120 Jhajjar114 Karnal104 Hisar98 Ambala93 Panipat78 Nuh68 Bhiwani60 Rewari56 Kurukshetra55 Sirsa50 Kaithal48 Mahendragarh47 CharkiDadri43 Panchkula39 Fatehabad38 Jind38 Yamunanagar19 |
6,15,897 13,548 |
1,16,867 758 |
4,93,425 12,639 |
5,605 151 |
|
DistrictCases Patna279 Bhagalpur266 Rohtas256 Khagaria253 Begusarai243 Madhubani199 Munger188 Jehanabad178 Katihar175 Darbhanga143 Samastipur139 Siwan139 PurbiChamparan138 Purnia135 Banka134 Buxar134 Nalanda123 Gopalganj123 Nawada122 Sheikhpura118 Gaya115 Kaimur (bhabua)105 Bhojpur103 Saran101 Muzaffarpur96 Saharsa88 Supaul87 Vaishali87 Madhepura82 Kishanganj75 Aurangabad75 Sitamarhi73 Lakhisarai72 Araria68 Pashchim Champaran57 Arwal52 Jamui47 Sheohar20 |
5,91,476 11,259 |
1,10,805 2,172 |
4,77,389 13,364 |
3,282 67 |
|
DistrictCases Ganjam581 Jajapur322 Khordha238 Baleshwar190 Kendrapara164 Cuttack155 Bhadrak137 Balangir129 Puri103 Sundargarh102 Jagatsinghapur91 Nayagarh86 Mayurbhanj73 Nuapada69 Gajapati61 Dhenkanal36 Boudh34 Kendujhar34 Deogarh33 Kalahandi33 Sonepur29 Kandhamal28 Anugul26 Malkangiri20 Bargarh16 Koraput16 Sambalpur16 Jharsuguda8 Nabarangpur2 Rayagada2 |
5,34,842 10,635 |
84,799 2,075 |
4,47,863 8,541 |
2,180 19 |
|
DistrictCases Hyderabad2,475 Ranga Reddy183 Suryapet87 Jagitial77 Nizamabad76 MedchalMalkajgiri75 Mancherial43 YadadriBhuvanagiri40 Jogulamba Gadwal40 Vikarabad40 Nalgonda33 Warangal Urban32 Mahabubnagar30 Sangareddy26 Khammam26 Adilabad22 Nirmal21 Karimnagar17 RajannaSircilla16 Medak11 Kamareddy11 Mahabubabad10 Jayashankar Bhupalapally9 Nagarkurnool8 Kumuram Bheem Asifabad8 Jangoan8 Siddipet7 Peddapalli5 Bhadradri Kothagudem5 Warangal Rural4 Mulugu3 Narayanpet3 Wanaparthy1 |
4,97,361 4,976 |
65,757 2,705 |
4,28,865 7,646 |
2,739 35 |
|
DistrictCases Amritsar485 Jalandhar297 Ludhiana293 Tarn Taran163 Gurdaspur154 Hoshiarpur140 S.A.S Nagar137 Patiala132 Sangrur107 Shahid Bhagat Singh Nagar (Nawanshahr)99 Pathankot86 Rupnagar (Ropar)74 Faridkot74 Sri Muktsar Sahib71 Moga65 Bathinda60 Fatehgarh Sahib57 Fazilka53 Firozepur50 Kapurthala44 Mansa31 Barnala25 |
4,42,125 8,436 |
74,343 2,395 |
3,57,276 5,850 |
10,506 191 |
|
DistrictCases Kamrup Metro276 Golaghat203 Nagaon143 Hojai89 Dima Hasao86 Karimganj85 Tinsukia84 Cachar80 Dibrugarh61 Hailakandi57 Lakhimpur57 Marigaon50 Dhemaji47 Kamrup42 Kokrajhar37 Dhubri30 Charaideo29 Barpeta28 Udalguri28 Sonitpur27 Jorhat24 Nalbari23 Darrang20 Sivasagar20 Goalpara19 Biswanath16 Baksa14 KarbiAnglong13 Bongaigaon12 Chirang6 West KarbiAnglong5 South SalmaraMancachar4 Majuli2 |
2,92,368 3,299 |
37,352 794 |
2,53,340 4,045 |
1,676 48 |
|
DistrictCases East Singhbum170 Ranchi148 Hazaribagh110 Garhwa80 Ramgarh75 Koderma58 Simdega48 Dhanbad32 Gumla28 Palamu27 West Singhbhum21 SaraikelaKharsawan20 Giridih19 Bokaro16 Latehar14 Khunti10 Lohardaga8 Deoghar5 Dumka5 Pakur4 Jamtara2 Godda2 Chatra1 Sahebganj0 |
2,86,343 4,169 |
58,806 2,389 |
2,23,684 6,461 |
3,853 97 |
|
DistrictCases Dehradun370 Nainital323 Tehri Garhwal110 Haridwar94 Udam Singh Nagar83 Almora71 Champawat45 Pithoragarh43 Chamoli36 PauriGarhwal36 Bageshwar31 Rudraprayag30 Uttar Kashi24 |
2,44,273 5,890 |
74,114 2,940 |
1,66,431 2,770 |
3,728 180 |
|
DistrictCases Anantnag395 Srinagar300 Kulgam295 Baramulla271 Shopian255 Kupwara231 Bandipora175 Udhampur155 Ramban151 Jammu138 Budgam110 Pulwama108 Kathua53 Rajouri39 Ganderbal37 Poonch35 Doda27 Reasi26 Samba25 Kishtwar10 Mirpur0 Muzaffarabad0 |
2,16,932 5,190 |
49,248 2,713 |
1,64,958 2,423 |
2,726 54 |
|
DistrictCases Hamirpur117 Kangra105 Una41 Solan32 Chamba29 Bilaspur21 Mandi21 Sirmaur11 Shimla10 Kullu4 Kinnaur2 Lahaul And Spiti0 |
1,31,423 3,093 |
32,469 576 |
97,069 2,462 |
1,885 55 |
|
DistrictCases South Goa69 North Goa57 |
1,18,846 2,633 |
31,875 512 |
85,292 3,078 |
1,679 67 |
|
DistrictCases Pondicherry111 Mahe4 Karaikal2 Yanam0 |
71,709 1,633 |
14,034 449 |
56,710 1,158 |
965 26 |
|
DistrictCases Chandigarh313 |
50,207 895 |
8,511 6 |
41,128 879 |
568 10 |
|
DistrictCases Dhalai196 Sepahijala174 Gomati74 South Tripura53 Unakoti49 West Tripura45 Khowai24 North Tripura14 |
37,692 133 |
2,750 1 |
34,532 130 |
410 4 |
|
DistrictCases Churachandpur32 Kangpokpi26 Imphal West21 Thoubal18 Imphal East10 Tengnoupal9 Bishnupur7 Senapati6 Chandel5 Kamjong5 Ukhrul4 Jiribam3 Pherzawl3 Kakching2 Tamenglong2 Noney1 |
35,354 579 |
4,280 429 |
30,598 135 |
476 15 |
|
DistrictCases Changlang31 Papum Pare8 Lohit3 Namsai2 West Siang1 East Siang1 Upper Siang1 Tawang1 PakkeKessang1 West Kameng0 Upper Subansiri0 Tirap0 Siang0 Shi Yomi0 Anjaw0 Lower Subansiri0 Lower Dibang Valley0 Longding0 Leparada0 KurungKumey0 KraDaadi0 Kamle0 East Kameng0 Dibang Valley0 Lower Siang0 |
20,165 119 |
1,933 69 |
18,172 188 |
60 |
|
DistrictCases East Khasi Hills22 West Garo Hills5 South West Garo Hills4 North Garo Hills1 West Jaintia Hills1 West Khasi Hills1 East Garo Hills0 East Jaintia Hills0 Ribhoi0 South Garo Hills0 South West Khasi Hills0 |
19,720 418 |
2,899 221 |
16,593 179 |
228 18 |
|
DistrictCases Dimapur20 Mon8 Kohima7 Kiphire3 Tuensang3 Peren2 Phek1 Longleng0 Mokokchung0 Wokha0 Zunheboto0 |
16,150 237 |
2,809 98 |
13,201 136 |
140 3 |
|
DistrictCases Kargil77 LehLadakh43 |
15,317 138 |
1,443 31 |
13,719 105 |
155 2 |
|
DistrictCases East District3 South District3 North District0 West District0 |
9,878 227 |
2,637 109 |
7,074 116 |
167 2 |
|
DistrictCases Dadra And Nagar Haveli20 |
8,847 110 |
1,320 105 |
7,523 215 |
4 |
|
DistrictCases Kolasib11 Aizawl10 Mamit8 Lawngtlai2 Lunglei2 Saitual1 Champhai0 Hnahthial0 Khawzawl0 Saiha0 Serchhip0 |
7,623 72 |
1,847 104 |
5,755 172 |
21 4 |
|
DistrictCases South Andamans33 Nicobars1 North And Middle Andaman1 |
6,367 26 |
203 8 |
6,088 32 |
76 2 |
|
DistrictCases Lakshadweep District0 |
3,881 125 |
1,016 23 |
2,856 148 |
9 |