COVID-19 Not Just Lung Disease, Can Also Cause Dangerous Blood Clots: Experts | News

May 7, 2021 0 Comments



The prevalence of blood clot formation known as deep vein thrombosis (DVT) in hospitalised COVID-19 patients is 14-28 per cent, find studies

Highlights
  • COVID-19 infection is about blood vessels as much as about lungs: Experts
  • We are dealing with five-six such cases per week on average: Doctor
  • The virus invades blood vessels: Doctor

New Delhi: There is increasing evidence to suggest that COVID-19 is not just a disease of the lungs as initially thought but can also cause dangerous blood clots which need to be immediately retrieved to save limbs in some cases, say experts. Global studies have shown that the prevalence of blood clot formation known as deep vein thrombosis (DVT) in hospitalised COVID-19 patients is 14-28 per cent and is a lower 2-5 per cent for arterial thrombosis.

Also Read: COVID-19 Vaccine Delivery By Age May Mitigate Deaths And Severe Health Impacts: Study

The India experience is similar, said experts, stressing that the infection is about the blood vessels as much as about the lungs.

We are dealing with five-six such cases per week on average. This week it has been one a day of such complications, said Dr Ambarish Satwik, vascular and endovascular surgeon at Delhi’s Sir Ganga Ram Hospital.

The prevalence of blood clot formation in COVID-19 is high in patients who have conditions such as type-2 Diabetes Mellitus, although the exact incidence remains unknown, added Dr Amrish Kumar, consultant, cardio-thoracic vascular department, Aakash Healthcare in southwest Delhi’s Dwarka locality.

While DVT is a serious condition that occurs when a blood clot forms in a vein located deep inside the body, arterial thrombosis is a clot that develops in an artery. Arteries are blood vessels that carry oxygen-rich blood away from the heart to the body, while veins carry blood low in oxygen from the body back to the heart.

Dr Satwik drew attention to the COVID-clot connection in a tweet earlier this week in which he posted a picture of a blood clot cast retrieved from the lower limb arteries of a COVID-19 patient.

What COVID clots look like. COVID produces blood clots. The incidence of heart attack, stroke, or limb loss due to an arterial clot in COVID varies from 2 per cent-5 per cent. We pried these out of the lower limb arteries of a COVID patient. We were able to save the limb, Dr Satwik said on May 5.

Also Read: Chef Vikas Khanna Sends COVID-19 Emergency Relief Material To India

Explaining his tweet, which attracted a lot of attention and questions too, Dr Satwik said the COVID-19 patient had an acute circulatory cut off because of the clots, and the limb was threatened.

So we had to physically do a surgical procedure and extract these clots, otherwise there would have been gangrene, and he would have ended up with an amputation. We were successfully able to take the clots out and save the limb, the surgeon explained.

Authors of a Lancet paper published in November last year said studies suggested there is increased association between COVID-19 and the risk of thromboembolism (TE) or obstruction of a blood vessel by a blood clot. The authors of the paper concluded that TE rates of COVID-19 are high and associated with a higher risk of death.

We have been understanding the pathophysiology of COVID-19 for over a year now. When it first hit China and the global west, it was thought that it was typical viral pneumonia. Severe cases of acute COVID were being labelled as similar to the acute respiratory distress syndrome (ARDS), which leads to respiratory failure, Dr Satwik noted.

However, a series of autopsies on COVID patients and their lungs revealed that what the doctors were seeing was not typical ARDS. “…in addition to that, they were finding clots in the microcirculation of the lungs. So it was then kind of understood that COVID is as much a disease of blood vessels as much it’s a disease of the lungs,” Dr Satwik added. In a COVID-19 patient, when blood vessels are injured, they produce a protein that attracts platelets and other clotting factors that come together to form a clot, Dr Kumar added.

Also Read: Proning Do’s And Don’ts, What Experts Have To Say

Studies have shown that around 20 to 30 per cent of hospitalised COVID-19 patients have developed this complication, he told PTI.

Because blood vessels are everywhere on the body, these clots could form anywhere, Dr Satwik said. Some of these clots occupy big blood vessels and become macroscopic blood clots.

But otherwise we are seeing diffused microscopic clots in microcirculation in various organs, he noted.

According to a University of Oxford study published in April, the risk of rare blood clotting following COVID-19 is around 100 times greater than normal. The research found that the rare blood clotting known as cerebral venous thrombosis (CVT) — a blood clot of a cerebral vein in the brain — is more common after COVID-19 than in any of the comparison groups, with 30 per cent of these cases occurring in the under 30s.

The signals that COVID-19 is linked to CVT, as well as portal vein thrombosis a clotting disorder of the liver is clear, and one we should take note of, said Oxford’s Maxime Taquet, one of the authors of the study.

Explaining how the virus causes blood clots in COVID-19 patients, Dr Satwik said the virus is known to attach itself to the inner lining of the lung, and right next to these air sacs are very thin blood vessels or capillaries.

The virus invades these blood vessels and starts affecting the inner lining of these blood vessels which produces a dysfunction within the blood vessels which produces these clots, the surgeon said.

As a result, he said, some clinicians were using blood thinners as part of the treatment and getting success.

What we have understood is these micro clots need immediate retrieval in order to save the limbs, Dr Satwik added.

He also said it is very difficult to know the prevalence of clots in the entire population infected with COVID. Although it is difficult to determine the vulnerability of COVID-19, individuals with existing cardiovascular morbidities are the ones who will suffer thrombotic complications, Dr Satwik said.

According to Dr Kumar, in COVID-19 patients, the clots seem to form in the tiny vessels of the lungs rather than the major vessels, adding that clots in the lungs usually happen in the case of typical strokes or heart attacks or deep vein thrombosis.

Risk of COVID-19 patients associated with blood clots are stroke (clot in the cerebral artery), clots in the lungs, heart attack, deep vein thrombosis, and thrombosis in both upper and lower limb arteries. Stroke can cause paralysis, but we have not seen any such so far in our hospital, Dr Kumar added.

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(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

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World

15,52,00,384Cases

6,03,54,534Active

9,16,04,062Recovered

32,41,788Deaths

Coronavirus has spread to 192 countries. The total confirmed cases worldwide are 15,52,00,384 and 32,41,788 have died; 6,03,54,534 are active cases and 9,16,04,062 have recovered as on May 6, 2021 at 3:48 am.

India

2,14,91,598 414188Cases

36,45,164 78766Active

1,76,12,351 331507Recovered

2,34,083 3915Deaths

In India, there are 2,14,91,598 confirmed cases including 2,34,083 deaths. The number of active cases is 36,45,164 and 1,76,12,351 have recovered as on May 7, 2021 at 2:30 am.

State & District Details

State Cases Active Recovered Deaths

DistrictCases

Mumbai45,478

Thane13,660

Pune9,920

Mumbai Suburban5,363

Aurangabad1,974

Nashik1,575

Raigad1,462

Palghar1,421

Solapur1,291

Jalgaon1,039

Akola757

Nagpur692

Kolhapur646

Satara629

Ratnagiri350

Amravati291

Dhule228

Hingoli208

Jalna201

Ahmednagar190

Nanded176

Yavatmal150

Sangli145

Latur139

Osmanabad125

Sindhudurg114

Buldhana88

Parbhani78

gondia69

Beed54

Nandurbar42

Gadchiroli42

Bhandara41

Chandrapur32

Washim13

Wardha11

49,42,736 62,194

6,41,281 2,501

42,27,940 63,842

73,515 853

DistrictCases

Udupi1,176

Kalaburagi669

Yadgir538

Bengaluru Urban529

Raichur369

Mandya346

Belagavi337

Bidar219

Hassan205

Davangere204

Vijayapura201

Dakshina Kannada179

Chikkaballapura149

Mysuru107

Bagalkote103

Uttara Kannada95

Shivamogga67

Dharwad61

Ballari60

Gadag45

Bengaluru Rural40

Tumakuru36

Kolar29

Haveri24

Chikkamagaluru19

Chitradurga14

Koppal5

Kodagu4

Ramanagara3

Chamarajanagara0

17,90,104 49,058

5,17,095 29,787

12,55,797 18,943

17,212 328

DistrictCases

Kannur357

Kasaragod333

Palakkad224

Malappuram119

Kollam118

Thrissur106

Thiruvananthapuram104

Pathanamthitta98

Kozhikode90

Alappuzha76

Kottayam73

Ernakulam60

Idukki40

Wayanad36

17,86,396 42,464

3,91,253 15,249

13,89,515 27,152

5,628 63

DistrictCases

Gautam Buddha Nagar1,119

Agra933

Ghaziabad794

Meerut504

Lucknow386

Saharanpur298

Kanpur Nagar286

Moradabad252

Varanasi243

Hapur225

Aligarh215

Basti214

Amethi206

Rampur203

Jaunpur194

Firozabad190

Barabanki168

Gorakhpur166

Bulandshahr166

Siddharth Nagar159

Ghazipur159

Bijnor157

Deoria143

Azamgarh138

Sant Kabeer Nagar132

Mathura129

Ayodhya120

Muzaffarnagar117

Sambhal116

Sultanpur97

Ambedkar Nagar92

Maharajganj85

Amroha80

Rae Bareli78

Bahraich73

Kheri72

Kannauj69

Baghpat68

Kushi Nagar67

Bhadohi60

Ballia60

Gonda59

Etah52

Hardoi49

Balrampur49

Mau48

Mainpuri46

Etawah46

Hathras43

Unnao42

Jalaun41

Jhansi41

Shamli40

Chandauli38

Auraiya37

Farrukhabad36

Sitapur32

Prayagraj30

Banda27

Shahjahanpur25

Shravasti23

Budaun23

Mirzapur22

Bareilly17

Kasganj16

Pratapgarh15

Pilibhit15

Sonbhadra10

Kaushambi6

Kanpur Dehat4

Chitrakoot4

Lalitpur3

Hamirpur3

Mahoba3

Fatehpur3

14,25,916 26,622

2,59,844 2,630

11,51,571 28,902

14,501 350

DistrictCases

Chennai23,324

Chengalpattu1,314

Thiruvallur774

Villupuram509

Kanchipuram503

Tiruvannamalai496

Cuddalore477

Ariyalur444

Tirunelveli433

Tuticorin333

Kallakurichi324

Madurai322

Salem258

Coimbatore188

Virudhunagar185

Dindigul175

Perambalur133

Ranipet133

Thanjavur130

Theni129

Tiruchirappalli119

Ramanathapuram119

Tiruppur116

Kanniyakumari110

Tenkasi103

Nagapattinam99

Karur88

Namakkal83

Erode75

Vellore71

Thiruvarur67

Pudukkottai53

Sivaganga46

Tirupathur45

Krishnagiri43

The Nilgiris17

Dharmapuri15

12,97,500 24,898

1,31,468 3,157

11,51,058 21,546

14,974 195

DistrictCases

North West5,463

Central4,817

West4,768

New Delhi3,405

North3,059

East2,472

South East2,446

South West2,391

South2,329

North East1,914

Shahdara1,580

12,73,035 19,133

90,629 1,230

11,64,008 20,028

18,398 335

DistrictCases

Kurnool795

Krishna557

Guntur511

Anantapur428

East Godavari356

Chittoor319

Sri Potti Sriramulu Nell*296

Y.S.R.205

West Godavari199

Srikakulam183

Prakasam104

Visakhapatnam103

Vizianagaram23

12,28,186 21,954

1,82,329 11,741

10,37,411 10,141

8,446 72

DistrictCases

Kolkata2,777

Howrah1,435

24 Paraganas North1,031

Hooghly604

24 Paraganas South281

Maldah235

Dinajpur Uttar216

Coochbehar210

Birbhum206

Medinipur West159

Medinipur East153

Nadia139

Purba Bardhaman130

Murshidabad125

Bankura116

Darjeeling97

Jalpaiguri88

Paschim Bardhaman70

Purulia66

Dinajpur Dakshin50

Alipurduar39

Kalimpong18

Jhargram9

9,35,066 18,431

1,22,774 902

8,00,328 17,412

11,964 117

DistrictCases

Bilaspur100

Korba100

Mungeli87

Baloda Bazar85

Jashpur77

Janjgir-Champa56

Mahasamund54

Rajnandgaon52

Kabirdham52

Raigarh47

Raipur46

Balod41

Korea39

Durg31

Bemetara21

Kanker19

Balrampur17

Surguja14

Gariyaband10

Surajpur9

Dhamtari6

Bijapur2

Bastar2

Dantewada0

Kondagaon0

Narayanpur0

Sukma0

8,16,489 13,846

1,31,245 2,034

6,75,294 11,600

9,950 212

DistrictCases

Jaipur2,177

Jodhpur1,748

Udaipur724

Bharatpur563

Kota503

Nagaur500

Ajmer379

Dungarpur374

Pali352

Jhalawar329

Bhilwara250

Sikar231

Chittorgarh188

Tonk171

Jalore164

Rajsamand140

Sirohi130

Bikaner112

Banswara91

Alwar90

Churu81

Jhunjhunu64

Dausa61

Dholpur60

Baran59

Jaisalmer53

Barmer34

Hanumangarh31

SawaiMadhopur26

Karauli17

Pratapgarh14

Ganganagar8

Bundi5

7,02,568 17,532

1,98,010 1,327

4,99,376 16,044

5,182 161

DistrictCases

Ahmadabad17,125

Surat2,311

Vadodara1,555

Gandhinagar410

Mahesana159

Banas Kantha147

Bhavnagar146

Rajkot135

Arvalli134

Mahisagar125

Anand107

PanchMahals107

Patan105

SabarKantha101

Kachchh99

Kheda98

Jamnagar63

Bharuch56

Botad55

Surendranagar55

Valsad47

GirSomnath45

Dohad43

Chhotaudepur37

Naysari35

Junagadh31

Narmada25

DevbhumiDwarka22

Amreli16

Porbandar11

Tapi6

Dang5

Morbi4

6,45,972 12,545

1,47,525 599

4,90,412 13,021

8,035 123

DistrictCases

Indore3,839

Bhopal1,880

Ujjain799

Burhanpur351

Neemuch319

Jabalpur276

East Nimar266

Sagar228

Gwalior211

Khargone196

Dewas140

Dhar132

Mandsaur112

Morena109

Bhind87

Raisen71

Barwani60

Ratlam51

Rewa39

Shajapur39

Hoshangabad37

Vidisha37

Chhatarpur35

Betul35

Rajgarh31

Dindori29

Sheopur26

Damoh26

Satna24

Anuppur22

Panna20

Tikamgarh18

Sidhi17

Narsinghpur17

Chhindwara16

Agar Malwa15

Mandla15

Shivpuri15

Jhabua14

Shandol14

Singrauli13

Ashoknagar13

Datia12

Sehore12

Umaria10

Balaghat9

Guna8

Harda4

Alirajpur3

Katni3

Seoni2

Niwari0

6,37,406 12,421

88,614 630

5,42,632 12,965

6,160 86

DistrictCases

Gurugram2,950

Faridabad867

Sonipat404

Rohtak145

Palwal120

Jhajjar114

Karnal104

Hisar98

Ambala93

Panipat78

Nuh68

Bhiwani60

Rewari56

Kurukshetra55

Sirsa50

Kaithal48

Mahendragarh47

CharkiDadri43

Panchkula39

Fatehabad38

Jind38

Yamunanagar19

5,73,815 14,840

1,15,842 2,417

4,52,836 12,246

5,137 177

DistrictCases

Patna279

Bhagalpur266

Rohtas256

Khagaria253

Begusarai243

Madhubani199

Munger188

Jehanabad178

Katihar175

Darbhanga143

Samastipur139

Siwan139

PurbiChamparan138

Purnia135

Banka134

Buxar134

Nalanda123

Gopalganj123

Nawada122

Sheikhpura118

Gaya115

Kaimur (bhabua)105

Bhojpur103

Saran101

Muzaffarpur96

Saharsa88

Supaul87

Vaishali87

Madhepura82

Kishanganj75

Aurangabad75

Sitamarhi73

Lakhisarai72

Araria68

Pashchim Champaran57

Arwal52

Jamui47

Sheohar20

5,53,803 15,126

1,15,152 1,672

4,35,574 13,364

3,077 90

DistrictCases

Ganjam581

Jajapur322

Khordha238

Baleshwar190

Kendrapara164

Cuttack155

Bhadrak137

Balangir129

Puri103

Sundargarh102

Jagatsinghapur91

Nayagarh86

Mayurbhanj73

Nuapada69

Gajapati61

Dhenkanal36

Boudh34

Kendujhar34

Deogarh33

Kalahandi33

Sonepur29

Kandhamal28

Anugul26

Malkangiri20

Bargarh16

Koraput16

Sambalpur16

Jharsuguda8

Nabarangpur2

Rayagada2

5,00,162 10,521

74,784 3,650

4,23,257 6,854

2,121 17

DistrictCases

Hyderabad2,475

Ranga Reddy183

Suryapet87

Jagitial77

Nizamabad76

MedchalMalkajgiri75

Mancherial43

YadadriBhuvanagiri40

Jogulamba Gadwal40

Vikarabad40

Nalgonda33

Warangal Urban32

Mahabubnagar30

Sangareddy26

Khammam26

Adilabad22

Nirmal21

Karimnagar17

RajannaSircilla16

Medak11

Kamareddy11

Mahabubabad10

Jayashankar Bhupalapally9

Nagarkurnool8

Kumuram Bheem Asifabad8

Jangoan8

Siddipet7

Peddapalli5

Bhadradri Kothagudem5

Warangal Rural4

Mulugu3

Narayanpet3

Wanaparthy1

4,81,640 5,892

73,851 3,276

4,05,164 9,122

2,625 46

DistrictCases

Amritsar485

Jalandhar297

Ludhiana293

Tarn Taran163

Gurdaspur154

Hoshiarpur140

S.A.S Nagar137

Patiala132

Sangrur107

Shahid Bhagat Singh Nagar (Nawanshahr)99

Pathankot86

Rupnagar (Ropar)74

Faridkot74

Sri Muktsar Sahib71

Moga65

Bathinda60

Fatehgarh Sahib57

Fazilka53

Firozepur50

Kapurthala44

Mansa31

Barnala25

4,16,350 8,841

66,568 3,561

3,39,803 5,126

9,979 154

DistrictCases

Kamrup Metro276

Golaghat203

Nagaon143

Hojai89

Dima Hasao86

Karimganj85

Tinsukia84

Cachar80

Dibrugarh61

Hailakandi57

Lakhimpur57

Marigaon50

Dhemaji47

Kamrup42

Kokrajhar37

Dhubri30

Charaideo29

Barpeta28

Udalguri28

Sonitpur27

Jorhat24

Nalbari23

Darrang20

Sivasagar20

Goalpara19

Biswanath16

Baksa14

KarbiAnglong13

Bongaigaon12

Chirang6

West KarbiAnglong5

South SalmaraMancachar4

Majuli2

2,77,687 4,936

33,176 1,914

2,42,980 2,976

1,531 46

DistrictCases

East Singhbum170

Ranchi148

Hazaribagh110

Garhwa80

Ramgarh75

Koderma58

Simdega48

Dhanbad32

Gumla28

Palamu27

West Singhbhum21

SaraikelaKharsawan20

Giridih19

Bokaro16

Latehar14

Khunti10

Lohardaga8

Deoghar5

Dumka5

Pakur4

Jamtara2

Godda2

Chatra1

Sahebganj0

2,70,089 6,974

60,633 1,101

2,05,977 5,740

3,479 133

DistrictCases

Dehradun370

Nainital323

Tehri Garhwal110

Haridwar94

Udam Singh Nagar83

Almora71

Champawat45

Pithoragarh43

Chamoli36

PauriGarhwal36

Bageshwar31

Rudraprayag30

Uttar Kashi24

2,20,351 8,517

62,911 3,385

1,54,147 4,981

3,293 151

DistrictCases

Anantnag395

Srinagar300

Kulgam295

Baramulla271

Shopian255

Kupwara231

Bandipora175

Udhampur155

Ramban151

Jammu138

Budgam110

Pulwama108

Kathua53

Rajouri39

Ganderbal37

Poonch35

Doda27

Reasi26

Samba25

Kishtwar10

Mirpur0

Muzaffarabad0

2,01,511 4,926

41,666 2,038

1,57,283 2,836

2,562 52

DistrictCases

Hamirpur117

Kangra105

Una41

Solan32

Chamba29

Bilaspur21

Mandi21

Sirmaur11

Shimla10

Kullu4

Kinnaur2

Lahaul And Spiti0

1,18,729 3,942

27,756 1,854

89,236 2,043

1,737 45

DistrictCases

South Goa69

North Goa57

1,08,267 3,869

29,752 1,788

77,014 2,023

1,501 58

DistrictCases

Pondicherry111

Mahe4

Karaikal2

Yanam0

66,627 1,510

12,430 713

53,296 779

901 18

DistrictCases

Chandigarh313

47,552 759

8,420 57

38,591 693

541 9

DistrictCases

Dhalai196

Sepahijala174

Gomati74

South Tripura53

Unakoti49

West Tripura45

Khowai24

North Tripura14

36,849 315

2,292 165

34,153 149

404 1

DistrictCases

Churachandpur32

Kangpokpi26

Imphal West21

Thoubal18

Imphal East10

Tengnoupal9

Bishnupur7

Senapati6

Chandel5

Kamjong5

Ukhrul4

Jiribam3

Pherzawl3

Kakching2

Tamenglong2

Noney1

33,733 380

2,991 334

30,295 33

447 13

DistrictCases

Changlang31

Papum Pare8

Lohit3

Namsai2

West Siang1

East Siang1

Upper Siang1

Tawang1

PakkeKessang1

West Kameng0

Upper Subansiri0

Tirap0

Siang0

Shi Yomi0

Anjaw0

Lower Subansiri0

Lower Dibang Valley0

Longding0

Leparada0

KurungKumey0

KraDaadi0

Kamle0

East Kameng0

Dibang Valley0

Lower Siang0

19,634 222

1,858 82

17,717 140

59

DistrictCases

East Khasi Hills22

West Garo Hills5

South West Garo Hills4

North Garo Hills1

West Jaintia Hills1

West Khasi Hills1

East Garo Hills0

East Jaintia Hills0

Ribhoi0

South Garo Hills0

South West Khasi Hills0

18,630 347

2,351 216

16,086 129

193 2

DistrictCases

Dimapur20

Mon8

Kohima7

Kiphire3

Tuensang3

Peren2

Phek1

Longleng0

Mokokchung0

Wokha0

Zunheboto0

15,271 267

2,245 207

12,905 57

121 3

DistrictCases

Kargil77

LehLadakh43

14,909 98

1,432 62

13,326 160

151

DistrictCases

East District3

South District3

North District0

West District0

9,183 264

2,256 206

6,769 55

158 3

DistrictCases

Dadra And Nagar Haveli20

8,502 177

1,581 18

6,917 195

4

DistrictCases

Kolasib11

Aizawl10

Mamit8

Lawngtlai2

Lunglei2

Saitual1

Champhai0

Hnahthial0

Khawzawl0

Saiha0

Serchhip0

7,147 183

1,779 137

5,351 46

17

DistrictCases

South Andamans33

Nicobars1

North And Middle Andaman1

6,255 32

225 1

5,958 30

72 1

DistrictCases

Lakshadweep District0

3,528 152

1,146 17

2,374 134

8 1





Source

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